BRAF-targeted therapy and immune responses to melanoma

SF Ngiow; DA Knight; A Ribas; GA McArthur; MJ Smyth

Journal article

BRAF-targeted therapy and immune responses to melanoma

SF Ngiow, DA Knight, A Ribas, GA McArthur, MJ Smyth

Oncoimmunology | LANDES BIOSCIENCE | Published : 2013

DOI: 10.4161/onci.24462

Open access

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Abstract

Type I BRAF inhibitors and immunotherapy constitute two new exciting approaches for the treatment of advanced malignant melanoma. We have recently elucidated a role for host C-C chemokine receptor Type 2 (CCR2) in the antineoplastic effects of Type I BRAF inhibitors in mice, supporting the therapeutic potential of combining BRAF inhibitors with immunotherapy. © 2013 Landes Bioscience.

University of Melbourne Researchers

Prof Grant McArthur Author

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Grants

Awarded by Cancer Research Institute

Funding Acknowledgements

GAM declares financial research support from Pfizer, Novartis and Millenium. This work was supported by the National Health and Medical Research Council of Australia (NH&MRC) Program Grant (1013667), Project Grant (1002655) and the Victorian Cancer Agency. MJS received support from a NH&MRC Australia Fellowship. SN was supported by a Cancer Research Institute PhD scholarship. GM received support from a NH&MRC Practitioner Fellowship.